Side Effects
Liver Failure
The FDA pulled Rezulin off the market in March 2000 after receiving reports of 90 cases of liver failure. 63 of those cases resulted in death and 10 cases resulted in liver transplants.
Symptoms of liver toxicity include:
In addition to liver failure, Rezulin has also been linked to heart failure. In a study conducted before Rezulin's approval, researchers discovered that Rezulin caused abnormal thickening in the left ventricular wall of the heart. Thickening of the left ventricular wall can lead to heart failure. The results of this study were discarded because the study was not conducted properly.
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